analgesic effect — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4351	DAMGO	Dagol,DAGO,RX-783006	Opioid Receptor
	DAMGO (DAGO) is an opioid receptor agonist with the ability to affect the locomotive activity in rodents. Possible analgesic agent due to μ-opiod receptor interaction.		Opioid Receptor
T7416	WS-12		TRP/TRPV Channel
	WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 nM)		TRP/TRPV Channel
TN6989	Isotoosendanin	(1S,2S,4R,5S,6R,9S,10S,11R,13R,18S,20R)-20-(acetyloxy)-6-(furan-3-yl)-11,15,18-trihydroxy-5,10,14-trimethyl-3,8-dioxo-16-oxapentacyclo[12.3.3.01,13.02,1?.0?,?]icosan-4-yl acetate	Others
	Isotoosendanin ((1S,2S,4R,5S,6R,9S,10S,11R,13R,18S,20R)-20-(acetyloxy)-6-(furan-3-yl)-11,15,18-trihydroxy-5,10,14-trimethyl-3,8-dioxo-16-oxapentacyclo[12.3.3.01,13.02,1?.0?,?]icosan-4-yl acetate) is a limonoid isolated f...		Others
TN1517L	Cochinchinenin A		Others
	Cochinchinenin A is the material basis for the analgesic effect of Dragons Blood.		Others
T8410	ASP7663		TRP/TRPV Channel
	ASP7663 is a TRPA1 Receptor Agonist and exhibiting an abdominal analgesic effect in vivo.		TRP/TRPV Channel
TN1517	1-(2,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)propan-1-one	Cochinchinenin A	Others
	1-(2,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)propan-1-one (Cochinchinenin A) is the material basis for the analgesic effect of Dragons Blood.		Others
T30824	Cgp 29030A	Cgp29030A,Cgp-29030A	Others
	CGP 29030A is a new piperazine derivative with analgesic activity and significant inhibitory effect on potentially nociceptive dorsal horn neurons, which can be used to study painful disorders.		Others
T8209	Saikosaponin b3		Others
	Saikosaponin b3 is isolated from the roots of Bupleurum falcatum L.. Saikosaponin b3 inhibits ACTH-induced lipolysis in the fat cells and exhibits analgesic effects.		Others
T40045	Sivopixant	S-600918,Sivopixant	P2X Receptor
	Sivopixant (S-600918) (S-600918) is a potent and selective antagonist of P2X3 receptor (P2X3 IC 50 =4.2 nM; P2X2/3 IC 50 =1100 nM). Sivopixant shows strong analgesic effect .		P2X Receptor
T1407	(-)-Menthol	L-Menthol,Levomenthol,Menthomenthol,Menthacamphor	Opioid Receptor , Endogenous Metabolite , TRP/TRPV Channel
	(-)-Menthol (Levomenthol) is a levo isomer of menthol, an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic properties. When added to pharmaceuticals and foo...		Opioid Receptor , Endogenous Metabolite , TRP/TRPV Channel
T3S0509	Gaultherin		COX
	Gaultherin has analgesic, and anti-inflammatory activities.Gaultherin lacks gastric ulcerogenic effect, because of it released salicylate in intestine slowly, not in stomach and it left the cyclooxygenase-1 unaffected, w...		COX
T5S1889	Yunaconitine	Guayewuanine B	Others
	1. Yunaconitine (Guayewuanine B) has anti-inflammatory and analgesic actions. 2. Yunaconitine was shown to have anti-thermic effect in pyrexial rats when administered orally at a dose of 5 μg/kg. 3. Yunaconitine shows po...		Others
T50030	1-(2,4-difluorophenyl)guanidine hydrochloride		Others
	1-(2,4-difluorophenyl)guanidine hydrochloride is a compound that is a potent and selective inhibitor of the voltage-gated sodium channel Nav1.7, a key player in pain signaling. It is therefore able to reduce pain signali...		Others
T5S0661	Koumine		Others
	1. Koumine can treat the diabetic neuropathy. 2. Koumine has antineoplastic effect, may be a future breast cancer chemotherapeutic agent. 3. Koumine has a significant analgesic effect in rodent behavioral models of infla...		Others
T6S1885	Benzoylmesaconine	Mesaconine 14-benzoate	Others
	Benzoylmesaconine (Mesaconine 14-benzoate) is the most abundant component of Wutou decoction, which is widely used in China because of its therapeutic effect on rheumatoid arthritis. Benzoylmesconine has analgesic activi...		Others
T5S0045	Isofraxidin	6,8-Dimethoxyumbelliferone,Phytodolor	MMP , ERK , p38 MAPK , TLR , COX
	1. Isofraxidin (Phytodolor) protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective effect against LPS-induced ALI, and the prote...		MMP , ERK , p38 MAPK , TLR , COX
T3929	Kaurenoic acid	Kauren-19-Oic Acid,kaurenoate,kaur-16-en-18-oic acid	Others
	Kaurenoic acid (kaurenoate) has anti-inflammatory potential in acetic acid-induced colitis, decreases in MDA level. Kaurenoic acid exerts a uterine relaxant effect acting principally through calcium blockade and in part,...		Others
TN4379	Kansuinine A		IL Receptor , STAT , Interleukin
	Kansuinine A possesses analgesic props, it also shows NGF inducing activity.		IL Receptor , STAT , Interleukin
T6S1699	Shogaol	[6]-Shogaol,6-Shogaol	Lipoxygenase , Autophagy
	1. 6-Shogaol (6-Shogaol) has antipyretic and analgesic effects in addition to inhibitory effect on lipoxygenase activity. 2. 6-shogaol has anti-inflammatory property, reduces the inflammatory response and protected the f...		Lipoxygenase , Autophagy
T23944	DA 5018	DA-5018,DA5018
	DA 5018 is a capsaicin derivative and is also a new non-narcotic analgesic. It has an antipruritic effect.